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Contraindicated. CYP3A4 is liable for the formation and elimination of cariprazine's Lively metabolites. The outcome of CYP3A4 inducers on cariprazine exposure has not been evaluated as well as Web outcome is unclear.pentobarbital will reduce the extent or effect of alosetron by affecting hepatic enzyme CYP2C9/ten metabolism. Slight/Significance Un